منابع مشابه
Combinatorial protein design.
Combinatorial protein libraries permit the examination of a wide range of sequences. Such methods are being used for denovo design and to investigate the determinants of protein folding. The exponentially large number of possible sequences, however, necessitates restrictions on the diversity of sequences in a combinatorial library. Recently, progress has been made in developing theoretical tool...
متن کاملCombinatorial protein design by in vitro recombination.
DNA recombination is a powerful engine for the creation of new phenotypes. Recently, methods for in vitro DNA recombination (DNA shuffling) have been developed and applied to the evolution of novel molecules in the laboratory. An exciting new development is the shuffling of homologous genes to create diversity for directed evolution.
متن کاملIn Silico Protein Design: A Combinatorial and Global Optimization Approach
The use of computational techniques to create peptideand protein-based therapeutics is an important challenge in medicine. The ultimate goal, defined about two decades ago, is to use computer algorithms to identify amino acid sequences that not only adopt particular three-dimensional structures but also perform specific functions. To those familiar with the field of structural biology, it is ce...
متن کاملDesign of combinatorial protein libraries of optimal size.
In this article we introduce a computational procedure, OPTCOMB (Optimal Pattern of Tiling for COMBinatorial library design), for designing protein hybrid libraries that optimally balance library size with quality. The proposed procedure is directly applicable to oligonucleotide ligation-based protocols such as GeneReassembly, DHR, SISDC, and many more. Given a set of parental sequences and the...
متن کاملCombinatorial Design Theory - Notes
Combinatorial design theory traces its origins to statistical theory of experimental design but also to recreational mathematics of the 19th century and to geometry. In the past forty years combinatorial design theory has developed into a vibrant branch of combinatorics with its own aims, methods and problems. It has found substantial applications in other branches of combinatorics, in graph th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2003
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.43.186